全文获取类型
收费全文 | 1009篇 |
免费 | 30篇 |
国内免费 | 4篇 |
专业分类
化学 | 793篇 |
晶体学 | 4篇 |
力学 | 21篇 |
数学 | 35篇 |
物理学 | 190篇 |
出版年
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 14篇 |
2017年 | 9篇 |
2016年 | 13篇 |
2015年 | 15篇 |
2014年 | 14篇 |
2013年 | 61篇 |
2012年 | 40篇 |
2011年 | 52篇 |
2010年 | 30篇 |
2009年 | 33篇 |
2008年 | 47篇 |
2007年 | 53篇 |
2006年 | 48篇 |
2005年 | 47篇 |
2004年 | 47篇 |
2003年 | 58篇 |
2002年 | 38篇 |
2001年 | 27篇 |
2000年 | 18篇 |
1999年 | 16篇 |
1998年 | 8篇 |
1997年 | 18篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 14篇 |
1993年 | 9篇 |
1992年 | 14篇 |
1991年 | 15篇 |
1990年 | 14篇 |
1989年 | 8篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 10篇 |
1985年 | 20篇 |
1984年 | 23篇 |
1983年 | 10篇 |
1982年 | 15篇 |
1981年 | 12篇 |
1980年 | 9篇 |
1979年 | 11篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1976年 | 8篇 |
1975年 | 7篇 |
1974年 | 9篇 |
1973年 | 11篇 |
1972年 | 6篇 |
排序方式: 共有1043条查询结果,搜索用时 31 毫秒
991.
Ellipsoidal anatase TiO2 nanoparticles of different aspect ratios were obtained by the gel-sol method in the presence of amino acids in which the resulting particles were basically single crystals, but highly rough surfaces or partly polycrystalline structures were observed with a high concentration of glutamic acid or aspartic acid. 相似文献
992.
Tatsumi Y Naga T Nakashima H Murahashi T Kurosawa H 《Chemical communications (Cambridge, England)》2004,(12):1430-1431
A series of 1,4-diphenyl-1,3-butadiene multinuclear palladium sandwich complexes are synthesized by stepwise growth of palladium chains within a sandwich framework. 相似文献
993.
Ohyama K Wada M Ohba Y Fujishita O Nakashima K Kuroda N 《Biomedical chromatography : BMC》2004,18(6):396-399
A capillary electrochromatographic (CEC) method was applied to the simultaneous separation of barbiturates (barbital, phenobarbital, secobarbital and thiopental) and benzodiazepines (nitrazepam, diazepam and triazolam). The separation was performed in a 75 microm i.d. capillary, packed with 3-(1,8-naphthalimido)propyl-modified silyl silica gel (NAIP), studying the effects of buffer pH and mobile phase composition. Using an applied voltage of 20 kV and the short-end injection method (9 cm capillary effective length), the mobile phase of 1.0 mM citrate buffer (pH 5.0) containing 45% methanol provided the baseline separation of seven toxic drugs in less than 9 min. In CEC with NAIP, the benzodiazepines were separated by the combination of hydrophobic and pi-pi interactions, whereas the separation of the barbiturates was based on the hydrophobic interaction. 相似文献
994.
T. Nagatomo K. Matsuta Y. Nakashima T. Sumikama M. Ogura K. Akutsu T. Iwakoshi H. Fujiwara T. Minamisono M. Fukuda M. Mihara T. Miyake K. Minamisono S. Momota Y. Nojiri A. Kitagawa M. Sasaki M. Torikoshi M. Kanazawa M. Suda M. Hirai S. Sato S. Y. Zhu J. Z. Zhu Y. J. Xu Y. N. Zheng J. R. Alonso G. F. Krebs T. M. Symons 《Hyperfine Interactions》2004,159(1-4):273-276
The momentum dependences of the nuclear spin polarization P and alignment A of 13B(, T
1/2 = 17.36 ms) produced in the 100A MeV 15N + Be collisions have been measured by detecting β-ray asymmetry. Because both the P and A were significantly smaller than the prediction from a simple kinematical model, some relaxation mechanisms must be take into
account. Comparing the signs of the observed alignment of 12B, the sign of the quadrupole coupling constant eqQ of 13B in TiO2 was determined to be positive. 相似文献
995.
Naganawa S Koshikawa T Fukatsu H Ishigaki T Sato E Sugiura M Yoshino T Nakashima T 《Magnetic resonance imaging》2004,22(1):25-30
Pendred syndrome (PDS) is characterized by profound deafness in childhood, positive perchlorate challenge, and goiter. PDS is often associated with enlarged endolymphatic duct and sac (EEDS), and recently, PDS gene mutations have been reported even in those patients with EEDS without classic Pendred syndrome. In a previous report, the number of mutant alleles was correlated with the degree of subclinical thyroid abnormality, but not with hearing loss, in patients with missense mutation H723R. It also has been reported that the hearing loss in EEDS was not correlated with the EEDS volume, cochlear modiolar area, or signal intensity of the endolymphatic sac. We evaluated the correlations between the number of mutant alleles and these parameters in patients with EEDS to investigate the mechanisms underlying this condition. The study group was comprised of 16 Japanese patients with EEDS diagnosed by MR imaging. The H723R mutation was homozygous in six patients and heterozygous in six patients, with no mutation found in four patients. The modiolar area, EEDS volume, and signal intensity ratio (sac signal/cerebrospinal fluid signal) were not significantly correlated with the number of mutant alleles. PDS gene mutations may not be the only cause of EEDS, and the mechanisms underlying EEDS remain unclear. 相似文献
996.
997.
Tamamura H Hiramatsu K Mizumoto M Ueda S Kusano S Terakubo S Akamatsu M Yamamoto N Trent JO Wang Z Peiper SC Nakashima H Otaka A Fujii N 《Organic & biomolecular chemistry》2003,1(21):3663-3669
A CXCR4 antagonistic peptide, T140, and its bio-stable analogs, such as Ac-TE14011, were previously developed. These peptides inhibit the entry of T cell line-tropic strains of HIV-1 (X4-HIV-1) into T cells. Herein, a series of TE14011 analogs having modifications in the N-terminal region were synthesized to develop effective compounds with increased biostability. Among these analogs, 4F-benzoyl-TE14011 (TF14013) showed the strongest anti-HIV activity derived from CXCR4-antagonism, suggesting that a 4-fluorobenzoyl moiety at the N-terminus of T140 analogs constitutes a novel T140-based pharmacophore for CXCR4 antagonists. Structure-activity relationship (SAR) studies on TE14011 analogs with N(alpha)-acylation by several benzoic acid derivatives have disclosed a significant relationship between the anti-HIV activity and the Hammett constant (sigma) of substituted benzoic acids. TF14013 was found to be stable in mouse serum, but not completely stable in rat liver homogenate due to deletion of the C-terminal Arg14-NH2 from the parent peptide. This biodegradation was completely suppressed by N-alkyl-amidation at the C-terminus. Taken together, the enhancement of the T140-based pharmacophores led to development of a novel CXCR4 antagonist, 4F-benzoyl-TE14011-Me (TF14013-Me), which has very high anti-HIV activity and increased biostability. 相似文献
998.
The axial position of a laser-trapped particle has been controlled by modification of the wave front by means of a membrane deformable mirror. The mirror gives wave-front modulation in terms of Zernike polynomials. By modulation of the Zernike defocus term we can modulate the particle position under conditions of laser trapping. A polystyrene particle of 1-microm diameter was moved along the optical axis direction for a distance of 2370 nm in minimum steps of 55.4 nm. We also demonstrated particle oscillation along the optical axis by changing the focal position in a sinusoidal manner. From the frequency dependency of the amplitude of particle oscillation we determined the spring constant as 91.7 nN/m. 相似文献
999.
This paper describes highly sensitive HPLC methods for the determination of amphetamine (AP) and methamphetamine (MP) in abusers' plasma and hair samples. AP and MP were derivatized with the fluorescent reagent, DIB-Cl, to yield a highly fluorescent DIB-derivatives of AP and MP, which were then analyzed by HPLC with fluorescence detection at excitation and emission wavelengths of 325 and 430 nm, respectively. The separation was achieved on an ODS column with isocratic mobile phases composed of acetoniltrile and citrate buffer (55:45, v/v) for plasma samples and of acetonitrile-methanol-citrate buffer (45:20:37.5, v/v/v) for hair samples. The limits of detection were less than 0.87 ng/mL and 0.12 ng/mg in plasma and hair samples, respectively, for both AP and MP. The methods were then applied to the determination of MP and its metabolite AP in plasma obtained from two cases of illegally ingested MP and in one of the cases' hair received later. Case I was treated with dialysis; samples before and after dialysis were analyzed by the described method. After dialysis for 5 h, the total plasma levels of AP and MP decreased from 720 to 190 ng/mL. For case II, MP and AP levels were monitored for 3 days after digestion. Total plasma levels decreased from 57 ng/mL in the day of digestion to 11 ng/mL after 3 days. In hair samples, AP and MP could also be detected in very low concentrations. 相似文献
1000.
Eiji Nakashima 《Annals of the Institute of Statistical Mathematics》1997,49(1):101-115
To clarify the advantage of using the quasilikelihood method, lack of robustness of the maximum likelihood method was demonstrated for the negative-binomial model. Efficiency calculations of the method of moments and the pseudolikelihood method in the estimation of extra-Poisson parameters in a negative-binomial model were carried out. Especially when the overdispersion parameter is small, both methods are relatively highly efficient and the pseudolikelihood estimate is more efficient than the method of moments estimate. Two examples of the quasilikelihood analyses of count data with overdispersion are given. The bootstrap method also is applied to the data to illustrate the advantage of the method of moments or pseudolikelihood method in the estimation of the standard errors of the mean parameter estimates under the negative-binomial model. 相似文献